What is MTHFR and Methylation

The Vital Role of Methylation in Human Health

What is Methylation?

Methylation is a biochemical process that occurs billions of times per second in every cell of the human body. It involves the transfer of a methyl group (CH₃) to DNA, proteins, and other molecules. This process regulates genetic expression, detoxification, energy production, cellular repair, and neurological function.

Healthy methylation is essential for maintaining overall health, preventing disease, and supporting longevity. When methylation is impaired—due to genetic mutations or environmental insults—it can lead to fatigue, cognitive decline, infertility, depression, cardiovascular problems, and even cancer.

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Methylation’s Core Functions

1. Energy Production

• Methylation supports mitochondrial function and ATP synthesis.
  
  

• It aids in the generation of creatine and carnitine—critical compounds for muscular energy.
  
  

• It helps regulate adrenal hormones, supporting resilience to stress.
  
  

2. DNA Protection, Repair, and Replication

• Methylation silences genes that could lead to cancer or inflammation if overexpressed.
  
  

• It plays a central role in DNA repair processes, protecting against mutations and premature aging.
  
  

• It ensures accurate cell division, critical during embryonic development, tissue regeneration, and immune response.
  
  

3. Detoxification

• Methylation contributes to Phase II liver detox pathways, especially in the metabolism of heavy metals, estrogens, and histamine.
  
  

• It aids glutathione recycling, boosting the body’s primary antioxidant defense system.
  
  

4. Cellular Repair and Regeneration

• Methylation regulates stem cell differentiation and cell membrane repair.
  
  

• It maintains cellular structure and function by controlling inflammation and promoting healthy cellular turnover.
  
  

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Understanding MTHFR Mutations

What is the MTHFR Gene?

The MTHFR (methylenetetrahydrofolate reductase) gene encodes an enzyme that helps convert folic acid and folate into their active form—5-methyltetrahydrofolate (5-MTHF). This conversion is crucial for generating methyl groups needed in the methylation cycle.

Types of MTHFR Mutations

There are two common MTHFR mutations:

• C677T
  
  

• A1298C
  
  

An individual can inherit:

• One mutation from a single parent (heterozygous)
  
  

• Two mutations (homozygous), leading to a more significant impact
  
  

Consequences of MTHFR Mutations

• Reduced ability to process folate into 5-MTHF
  
  

• Impaired homocysteine regulation (elevated homocysteine is a risk for heart disease, stroke, and neurodegeneration)
  
  

• Increased susceptibility to anxiety, depression, infertility, and chronic fatigue
  
  

• Compromised detoxification and glutathione production
  
  

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Can MTHFR Mutations Be Acquired?

Although traditionally viewed as inherited, MTHFR dysfunction can also be induced or worsened by environmental and biological factors, including:

• Vaccines: Some adjuvants and preservatives (e.g., aluminum, mercury) may alter epigenetic expression of methylation pathways.
  
  

• Viruses: Chronic viral infections (like Epstein-Barr or COVID-19) can impair mitochondrial and methylation functions.
  
  

• Environmental Toxins: Pesticides, BPA, air pollutants, and heavy metals interfere with methylation by overloading detox pathways or damaging DNA.
  
  

• Poor Diet and Stress: Nutrient deficiencies and chronic stress deplete methyl donors and coenzymes.
  
  

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OG Vitality: Therapeutic Methylation Support

OG Vitality is uniquely formulated to support both inherited and acquired methylation issues with potent, bioavailable doses of key nutrients:

1. Trimethylglycine (TMG) – 500 mg per serving

• A powerful methyl donor, TMG plays a pivotal role in reducing homocysteine and supporting DNA repair.
  
  

• It enhances liver detoxification and fat metabolism, making it vital for cardiovascular health and energy.
  
  

• Most supplements include 100–250 mg—OG Vitality doubles that for clinical efficacy.
  
  

2. Methylcobalamin (B12) – 630 mcg per serving

• Active B12 is required for methyl group transfer and neurological function.
  
  

• OG Vitality includes three active forms: Methyl, Adenosyl, and Hydroxo B12—not synthetic cyanocobalamin.
  
  

• This blend ensures coverage for mitochondrial, neurological, and detox functions.
  
  

• Other formulas may contain only 100–250 mcg, often in the inactive cyanocobalamin form.
  
  

3. 5-Methyltetrahydrofolate (5-MTHF) – 800 mcg per serving

• This is the methylated form of folate that bypasses the MTHFR enzyme block.
  
  

• Critical for DNA synthesis, fetal development, and neurotransmitter balance.
  
  

• The 800 mcg dose is ideal for both daily maintenance and therapeutic methylation support—especially for those with MTHFR mutations.
  
  

• Most supplements use synthetic folic acid or include minimal 5-MTHF.
  
  

These therapeutic doses are designed not just to meet minimum daily requirements, but to optimize methylation, repair, and detoxification—especially for those under stress, with chronic illness, or genetic mutations.

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Full-Spectrum Methylation Benefits

For Individuals With MTHFR Mutations:

• Reduced homocysteine = lower risk of cardiovascular disease
  
  

• Improved neurotransmitter synthesis = better mood, focus, and sleep
  
  

• Enhanced DNA repair = lower cancer risk and improved cellular aging
  
  

• Restored detox capacity = protection from toxins, viruses, and inflammation
  
  

For Individuals Without MTHFR Mutations:

• Boosts energy, mental clarity, and stamina
  
  

• Enhances hormone balance and fertility
  
  

• Promotes longevity through DNA protection and cellular resilience
  
  

• Supports stress response and adrenal recovery
  
  

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How OG Vitality Goes Beyond the Norm

OG Vitality doesn't just stop at methylation—it amplifies its benefits by including synergistic ingredients:

• Riboflavin (B2), Pyridoxal-5-Phosphate (B6), and Niacinamide (B3) to activate and sustain the methylation cycle
  
  

• Choline and Phosphatidylcholine for cell membrane repair and neurotransmitter synthesis
  
  

• Fulvic acid to enhance absorption and nutrient delivery at the cellular level
  
  

• Sea Buckthorn, Alpha Lipoic Acid, and CoQ10 to repair mitochondria and prevent oxidative stress
  
  

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Conclusion: Methylation is the Master Key to Wellness

Methylation touches every corner of our biology—from the way we age, think, and detox to our energy levels and immune function. Disruptions caused by MTHFR mutations or environmental toxins can severely compromise this process.

OG Vitality provides a superior, science-backed solution with therapeutic doses of:

• 500 mg Trimethylglycine
  
  

• 630 mcg Methylcobalamin (plus Adenosyl + Hydroxo)
  
  

• 800 mcg 5-MTHF
  
  

This OG Vitality Formula surpasses typical supplements in potency, purity, and effectiveness—unlocking the full potential of methylation to restore vitality, balance, and cellular harmony for everyone—whether genetically affected or not.

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